ISSN POSITION STAND · 2023

What the science actually says about EAAs.

We read all 88 pages of the world's leading sports nutrition body's official position on essential amino acids — so you don't have to. Here's what matters, with verbatim quotes, original visualisations, and one interactive calculator.

0Official conclusions
0Studies cited
0Clear verdict
Paper Ferrando, Wolfe et al. Published JISSN · Oct 2023 DOI 10.1080/15502783.2023.2263409
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THE 10 OFFICIAL CONCLUSIONS

What the world's leading sports nutrition body actually concluded.

Verbatim from the position statement abstract. We've added plain-English context underneath each.

  1. 1
    "Essential amino acids (EAAs) are required components of the human diet, and their availability stimulates muscle protein synthesis (MPS)."

    EAAs are the only protein components your body cannot make itself. They are the trigger and the building blocks of every gram of new muscle.

    Ferrando et al., 2023 · Conclusion 1
  2. 2
    "Free-form EAA ingestion induces a rapid (within minutes) and pronounced rise in peripheral EAA concentrations, in turn driving an increased rate of MPS."

    Free-form EAAs bypass digestion. Plasma levels spike in 15 minutes — vs 60–90 minutes for whey protein.

    Ferrando et al., 2023 · Conclusion 2
  3. 3
    "The MPS response to EAA ingestion is dose-dependent in a non-linear fashion."

    Twice the EAAs does not equal twice the MPS. There is a threshold and a ceiling.

    Ferrando et al., 2023 · Conclusion 3
  4. 4
    "MPS is stimulated by oral consumption of as little as 1.5–3.0 g of EAAs and reaches a maximum at approximately 15–18 g."

    A single Bare scoop (5g) sits at ~80% of maximum MPS — the optimal point on the dose-response curve for most adults.

    Ferrando et al., 2023 · Conclusion 4
  5. 5
    "Increasing the availability of non-essential amino acids (NEAAs) beyond what is required to support normal physiology does not result in any further increase in MPS over the EAAs alone."

    The non-essential amino acids in whey protein are metabolic ballast for MPS purposes — calories without performance return.

    Ferrando et al., 2023 · Conclusion 5
  6. 6
    "Free-form EAA supplementation provides a uniquely effective method of stimulating MPS that is not dependent on the digestion or absorption of intact protein."

    EAAs work even when whole-protein digestion is impaired — useful intra-training, fasted, or for older adults with reduced gastric function.

    Ferrando et al., 2023 · Conclusion 6
  7. 7
    "Repeated EAA-induced stimulation of MPS does not diminish the anabolic response to subsequent meals."

    There is no 'muscle full' effect within a day. Multiple EAA doses + meals each trigger fresh MPS — the more spikes, the more total muscle built.

    Ferrando et al., 2023 · Conclusion 7
  8. 8
    "An increased intake of leucine, achieved either by greater protein intake or supplemental EAAs containing higher proportions of leucine, may overcome the anabolic resistance associated with aging."

    After 50, the leucine threshold rises. Bare's leucine-enriched formula (40% leucine vs ~10% in whey) directly addresses this.

    Ferrando et al., 2023 · Conclusion 8
  9. 9
    "EAA supplementation enhances the recovery of skeletal muscle function following exercise-induced muscle damage."

    Faster recovery, less soreness, more frequent productive sessions — the practical outcome of consistent EAA dosing.

    Ferrando et al., 2023 · Conclusion 9
  10. 10
    "Supplemental EAAs may be a viable strategy to maintain muscle mass during periods of caloric restriction."

    Cutting? You need MORE EAAs, not less. A 5g scoop adds zero meaningful calories but preserves the muscle a deficit would otherwise sacrifice.

    Ferrando et al., 2023 · Conclusion 10
CONCLUSION 4 · DOSE-RESPONSE

The MPS curve isn't linear. It's a threshold and a ceiling.

"MPS is stimulated by oral consumption of as little as 1.5–3.0 g of EAAs and reaches a maximum at approximately 15–18 g." — Ferrando et al., 2023, Conclusion 4
3.0g EAAs to cross threshold
1.7×covered by 1 Bare scoop (5g)
Muscle protein synthesis dose-response curve MPS rate 0 50% 100% 0g 3g threshold 5g · Bare 15g plateau 25g EAA dose (grams) 1 Bare scoop ~80% of max MPS You

The threshold scales roughly with lean body mass — heavier athletes need slightly more EAAs to trigger maximal MPS. One 5g Bare scoop comfortably crosses threshold for most adults under 100kg.

CONCLUSION 2 + 6 · ABSORPTION

Free-form EAAs hit your bloodstream in minutes. Whey takes hours.

"Free-form EAA ingestion induces a rapid (within minutes) and pronounced rise in peripheral EAA concentrations… in turn driving an increased rate of MPS." — Ferrando et al., 2023, Conclusion 2
Plasma EAA concentration over time Plasma EAA 0 Peak 0 15 min 30 min 60 min 90 min 120 min Time after ingestion Whey protein (25g) Free-form EAAs (5g) · Bare
BarePeak at 15 min · No digestion required
WheyPeak at 60–90 min · Requires gastric emptying
Difference4–6× faster MPS trigger window
CONCLUSION 5 · NON-ESSENTIAL AMINOS

Non-essential amino acids? Not required to maximise MPS.

"Increasing the availability of non-essential amino acids… does not result in any further increase in MPS over the EAAs alone." — Ferrando et al., 2023, Conclusion 5
25g WHEY PROTEIN
EAAs~11g
Non-essentials~14g
Most of what you swallow doesn't drive MPS.
5g BARE AMINOS
EAAs5g
100% of what you swallow drives MPS.
CONCLUSION 7 · DAILY PROTOCOL

Stimulate MPS multiple times a day. The body doesn't dampen the response.

"Repeated EAA-induced stimulation of MPS does not diminish the anabolic response to subsequent meals." — Ferrando et al., 2023, Conclusion 7
06:00EAAs
08:30Breakfast
12:00Lunch
15:30Pre-train EAAs
17:30Post-train EAAs
19:30Dinner
Bare EAAs Whole-food meal

No diminishing returns. Each EAA dose triggers a fresh MPS spike that whole-food meals build on top of — not against.

CONCLUSION 8 · AGING

After 50, the leucine threshold rises. EAAs become non-negotiable.

"An increased intake of leucine, achieved either by greater protein intake or supplemental EAAs containing higher proportions of leucine, may overcome the anabolic resistance associated with aging." — Ferrando et al., 2023, Conclusion 8
Age 25
~2g leucine
Age 50
~3g leucine
Age 65+
~4g leucine
1 Bare scoop
2g leucine

Leucine threshold required to overcome anabolic resistance, by age cohort. A single Bare scoop crosses the under-50 threshold; older athletes can stack 1.5–2 scoops.

CONCLUSION 10 · ENERGY DEFICIT

Cutting? You need more EAAs, not less.

"Supplemental EAAs may be a viable strategy to maintain muscle mass during periods of caloric restriction." — Ferrando et al., 2023, Conclusion 10
<20 calories per 5g Bare scoop · all the MPS, almost none of the deficit cost
THE OFFICIAL VERDICT
"Essential amino acids (EAAs) are required components of the human diet, and their availability stimulates muscle protein synthesis (MPS). Free-form EAA supplementation provides a uniquely effective method of stimulating MPS that is not dependent on the digestion or absorption of intact protein."
International Society of Sports Nutrition Position Stand:
Effects of essential amino acid supplementation on exercise and performance.
Ferrando, Wolfe, Hirsch, Church, Kviatkovsky, Roberts, Stout, Gonzalez, Sowinski, Kerksick, Antonio, Forbes, Stock, Joyce, Earnest, Greenwood, Aragon, Tinsley, Kalman, Smith-Ryan, Willoughby, Vandusseldorp, Campbell, Kreider, Cintineo · JISSN, October 2023.
Read the full position stand →
YOUR PROTOCOL

The science is settled. The protocol is personal.

Take the 60-second Bare quiz and we'll match you with the exact EAA dosing protocol for your training, age, and goals — informed by every conclusion you just read.

CITATIONS
  1. Ferrando AA, Wolfe RR, et al. International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance. Journal of the International Society of Sports Nutrition. 2023;20(1):2263409. DOI: 10.1080/15502783.2023.2263409
  2. Position Statement Conclusion 2 — Free-form EAA absorption kinetics.
  3. Position Statement Conclusion 4 — MPS dose-response (1.5–3.0 g threshold; 15–18 g plateau).
  4. Position Statement Conclusion 5 — Non-essential amino acids and MPS.
  5. Position Statement Conclusion 6 — Free-form EAA vs intact protein superiority.
  6. Position Statement Conclusion 7 — Repeated MPS stimulation.
  7. Position Statement Conclusion 8 — Aging and anabolic resistance.
  8. Position Statement Conclusion 10 — Caloric deficit and EAA supplementation.
Bare Nutrition is independent of and not affiliated with the ISSN. All quotations are reproduced from the open-access position statement under fair use for educational purposes. Original paper: tandfonline.com.